Cool News
Cool News · issue 2
Lo más relevante de la semana en longevidad y rejuvenecimiento.
This week's highlights in longevity and rejuvenation.
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Cool NewsNaked Mole Rat Hyaluronan Synthase 2 Improves Health in Mice But Doesn't Reduce Age-Related Hearing Loss
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to the progression of aging and species longevity. Differences in the presence of hyaluronan in the extracellular matrix are thought to improve the health and resilience of long-lived naked-mole rats, and so researchers generated a mouse lineage that manufactures naked mole rat hyaluronan. The result is improved healthspan, and so now researchers are beginning to assess this nove
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to
Fuente: Fight Aging!
Cool NewsBiophysical Therapeutics debuts longevity skincare product to fund drug research
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits fr
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits fr
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturize
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits from sales will be reinvested to fund the company’s drug programs targeting cancer, age-related diseases including Alzheimer’s disease, and aging itself. Biophysical Therapeutics […] The post Biophysical Therapeutics debuts longevity skincare product to fund drug research appeared first on Longevity.Technology .
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits fr
Fuente: Longevity.Technology
Cool NewsClearing Damaged Mitochondria to Fight Skin Photoaging
Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced […]
Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced […]
Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cel
Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced […]
Researchers publishing in Aging Cell have found that a cocktail of molecules released by human umbilical cord mesenchymal stem cells (hUC-MSCs) can mitigate sun-induced […]
Fuente: Lifespan.io
Cool NewsLung Fibrosis Drug Lowers Biological Age Estimates
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, […]
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, […]
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentoser
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, […]
Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, […]
Fuente: Lifespan.io
Cool NewsInvestigating Mechanisms by Which Mitochondrial Superoxide Promotes Longevity
Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine trip
Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine trip
Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increase
Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine triphosphate (ATP) to power the cell. Reactive oxygen species react with and damage molecular machinery throughout the cell, damage that needs to be repaired. The cell reacts with an increase in repair and maintenance activities that address oxidative damage and other forms of damage, producing a net benefit to function. Here, researchers investigate one portion of how this respons
Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine trip
Fuente: Fight Aging!
Cool NewscGAS Knockout Reduces Cellular Senescence in Aged Killifish, But Does Not Extend Life
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some frac
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some frac
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the infl
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some fraction of the maladaptive chronic inflammation characteristic of aging, as, among other reasons, mitochondrial dysfunction tends to spill mitochondrial DNA fragments into the cell cytoplasm. Nothing in the cell has only one purpose, however, and cGAS is also involved in the regulation of the DNA damage response in the cell nucleus. It is known to inhibit homologous recombination
The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING interaction produces some frac
Fuente: Fight Aging!
Cool NewsBioViva patents dual-gene approach to aging
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease. Patents don’t usually make headlines. This one probably shouldn’t either, exce
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease. Patents don’t usually make headlines. This one probably shouldn’t either, exce
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-relat
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease. Patents don’t usually make headlines. This one probably shouldn’t either, except for what it’s protecting. A company just secured legal ground around a strategy that treats aging itself as the target, rather than any single disease […] The post BioViva patents dual-gene approach to aging appeared first on Longevity.Technology .
New patent covers combining hTERT and Follistatin-344 to target telomere length, muscle mass and blood-glucose levels in age-related disease. Patents don’t usually make headlines. This one probably shouldn’t either, exce
Fuente: Longevity.Technology
Cool NewsPeer-reviewed study finds favorable cognitive outcomes from RestoreU
UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented favorable cognitive outcomes associated with its AI-supported RestoreU care plans. The retros
UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented favorable cognitive outcomes associated with its AI-supported RestoreU care plans. The retros
UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented fav
UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented favorable cognitive outcomes associated with its AI-supported RestoreU care plans. The retrospective, nonrandomized implementation-and-outcomes analysis reviewed 345 paired cognitive tests over a mean follow-up of 14.1 months and, according to the company, found that 83.5% of patients improved, […] The post Peer-reviewed study finds favorable cognitive outcomes from RestoreU appeared first on Longevity.Technology .
UMethod Health published a peer-reviewed, real-world study in Current Aging Science that, according to the company, documented favorable cognitive outcomes associated with its AI-supported RestoreU care plans. The retros
Fuente: Longevity.Technology
Cool NewsOtras novedades de la semana que merecen un minuto.
Rationing of sugar in the United Kingdom in the years immediately following the Second World War forms a natural experiment in the long term effects of changes in human nutrition that can be explored
A range of gene therapies are presently available in the medical tourism community of clinics outside the US and Europe, largely originating with a small number of companies such as BioViva Sciences a
A new connector lets Function Health members bring lab results and biomarker trends straight into Meta’s personal AI agent, Muse. A particular kind of frustration is getting a stack of lab results bac
A magnet-producing bacterium extended the average lifespan of C. elegans worms by more than 43% while helping protect their neurological and intestinal health. Researchers traced much of the effect to
Cancer rates are rising in adults under 55, and new research suggests accelerated biological aging may be one piece of the puzzle. Scientists found that people from more recent generations tended to h
Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart's ability to process energy. Mitochondrial transplantation was found to be
It is well understood in the aging research community that the lack of a useful, consensus measure of biological age or pace of biological aging is a considerable hindrance to progress. If researchers
Researchers here take a very broad tour of the established literature on the comparative biology of aging in long lived species of all sorts, picking from those that can live more than 250 years, whet
Senescent cells accumulate with age, likely largely because the aging of the immune system slows down the clearance of senescent cells, but the relative importance of different contributions to the gr
Cool NewsCool News advice column
Aquí respondemos las dudas que llegan a nuestra Comunidad. Esta semana, dos casos que dan que pensar.
Responde: Equipo médico de Cool News
¿Quieres que tu caso salga aquí? Cuéntalo en nuestra Comunidad y el especialista lo responderá.
Cool NewsNaked Mole Rat Hyaluronan Synthase 2 Improves Health in Mice But Doesn
Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to the progression of aging and species longevity. Differences in the presence of hyaluronan in the extracellular matrix are thought to improve the health and resilience of long-lived naked-mole rats, a
¿Qué se puede hacer hoy con esta información y qué límites tiene?
Ante un caso así, lo primero es ponerlo en contexto: lo que se ha documentado en un estudio o en un caso publicado no equivale a una recomendación para una persona concreta.
Antes de cambiar nada conviene tener una línea base medida (analítica básica, sueño, actividad, composición corporal) y comentarlo con un profesional que conozca tu historial.
Los hábitos con más respaldo siguen siendo los poco espectaculares: dormir con horario estable, entrenar fuerza, comer proteína suficiente y no pasar el día sentado.
Fuente del caso: Fight Aging!
Contenido informativo: no constituye consejo médico ni sustituye la consulta con un profesional sanitario.
Cool NewsBiophysical Therapeutics debuts longevity skincare product to fund dru
Biophysical Therapeutics has launched IF1, a consumer longevity skincare brand, and opened pre-orders for an anti-aging moisturizer. The initial production run is limited to 500 units, priced at $120 each, and profits from sales will be reinvested to fund the company’s drug programs targeting cancer, age-related diseases including Alzheimer’s disease, and aging itself. Biophysical Therapeutics […] The post Biop
¿Qué se puede hacer hoy con esta información y qué límites tiene?
Ante un caso así, lo primero es ponerlo en contexto: lo que se ha documentado en un estudio o en un caso publicado no equivale a una recomendación para una persona concreta.
Antes de cambiar nada conviene tener una línea base medida (analítica básica, sueño, actividad, composición corporal) y comentarlo con un profesional que conozca tu historial.
Los hábitos con más respaldo siguen siendo los poco espectaculares: dormir con horario estable, entrenar fuerza, comer proteína suficiente y no pasar el día sentado.
Fuente del caso: Longevity.Technology
Contenido informativo: no constituye consejo médico ni sustituye la consulta con un profesional sanitario.
Cool NewsThis week's advice
Seis hábitos con respaldo suficiente para empezar hoy mismo, sin promesas milagrosas.
Keep a fixed sleep schedule
Acostarte y levantarte a la misma hora estabiliza el ritmo circadiano, y el sueño profundo es cuando el cerebro limpia desechos metabólicos.
Going to bed and waking at the same time stabilises your circadian rhythm, and deep sleep is when the brain clears metabolic waste.
Strength-train twice a week
La masa muscular es uno de los mejores predictores de autonomía con la edad. Dos sesiones semanales ya marcan una diferencia medible.
Muscle mass is one of the best predictors of independence with age. Two weekly sessions already make a measurable difference.
Eat enough protein
Reparte entre 1,2 y 1,6 g de proteína por kilo de peso al día para sostener el músculo y la reparación celular.
Spread 1.2–1.6 g of protein per kilo of body weight per day to support muscle and cellular repair.
Move every hour
Estar sentado mucho tiempo se asocia a peor salud metabólica incluso en personas que entrenan. Levántate y camina unos minutos cada hora.
Long sitting hours are linked to worse metabolic health even in people who train. Stand up and walk for a few minutes every hour.
Measure before you change
Un análisis básico —glucosa, lípidos, inflamación, vitamina D— te da una línea base. Sin medir no sabes si algo funciona.
A basic panel —glucose, lipids, inflammation, vitamin D— gives you a baseline. Without measuring, you cannot tell whether anything works.
Protect your social ties
El aislamiento sostenido pesa sobre la salud como otros factores clásicos. Mantener vínculos reales es longevidad, no solo bienestar.
Sustained isolation weighs on health like other classic risk factors. Keeping real relationships is longevity, not just wellbeing.
Esta edición se generó en modo automático de reserva.
Eleva tus niveles de NAD+ y vitalidad celular
Conoce tu edad biológica real mediante análisis de sangre y ADN
Recuperación muscular criogénica y shock térmico mitocondrial
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Carácter Divulgativo: El contenido publicado en Cool Items (artículos de la Revista, investigaciones sobre longevidad, suplementación o protocolos celulares) tiene carácter estrictamente informativo y educativo. En ningún caso constituye asesoramiento médico, diagnóstico facultativo ni tratamiento, ni sustituye el criterio de un profesional sanitario colegiado (conforme al RD 1907/1996 y Reglamento CE 1924/2006). Consulta siempre a tu médico antes de iniciar cualquier pauta de salud.
Transparencia en Publicaciones: En estricto cumplimiento del art. 20 de la LSSI-CE, informamos que Cool Items colabora y participa en programas de afiliación de bienestar y biotecnología. Algunos enlaces incluidos en nuestras recomendaciones pueden ser de afiliados, lo que significa que podemos recibir una comisión sin ningún coste adicional para el usuario, manteniendo siempre criterios de máxima exigencia y rigor editorial.
